Pathways, Processes, and Candidate Drugs Associated with a Hoxa Cluster-Dependency Model of Leukemia

High expression of the HOXA cluster correlates with poor clinical outcome in acute myeloid leukemias, particularly those harboring rearrangements of the mixed-lineage-leukemia gene (MLLr). Whilst decreased HOXA expression acts as a readout for candidate experimental therapies, the necessity of the H...

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Udgivet i:Cancers (Basel)
Main Authors: Kettyle, Laura M., Lebert-Ghali, Charles-Étienne, Grishagin, Ivan V., Dickson, Glenda J., O’Reilly, Paul G., Simpson, David A., Bijl, Janet J., Mills, Ken I., Sauvageau, Guy, Thompson, Alexander
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6966468/
https://ncbi.nlm.nih.gov/pubmed/31861091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11122036
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