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NUP98–HOXA9 expression in hemopoietic stem cells induces chronic and acute myeloid leukemias in mice
Here we describe hemopoietic chimeras serving as a mouse model for NUP98–HOXA9-induced leukemia, which reproduced several of the phenotypes observed in human disease. Mice transplanted with bone marrow cells expressing NUP98–HOXA9 through retroviral transduction acquire a myeloproliferative disease...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2001
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC133485/ https://ncbi.nlm.nih.gov/pubmed/11157742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/20.3.350 |
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