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(S)-10-Hydroxycamptothecin Inhibits Esophageal Squamous Cell Carcinoma Growth In Vitro and In Vivo Via Decreasing Topoisomerase I Enzyme Activity

Topoisomerase (TOP) I plays a major role in the process of supercoiled DNA relaxation, thereby facilitating DNA replication and cell cycle progression. The expression and enzymatic activity of TOP I is positively correlated with tumor progression. Although the anticancer activity of (S)-10-Hydroxyca...

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Bibliografiske detaljer
Udgivet i:Cancers (Basel)
Main Authors: Song, Mengqiu, Yin, Shuying, Zhao, Ran, Liu, Kangdong, Kundu, Joydeb Kumar, Shim, Jung-Hyun, Lee, Mee-Hyun, Dong, Zigang
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6966462/
https://ncbi.nlm.nih.gov/pubmed/31817790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11121964
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