Probenecid‐Boosted Tenofovir: A Physiologically‐Based Pharmacokinetic Model‐Informed Strategy for On‐Demand HIV Preexposure Prophylaxis

Multiple doses of tenofovir disoproxil fumarate (TDF) together with emtricitabine is effective for HIV preexposure prophylaxis (PrEP). TDF is converted to tenofovir (TFV) in circulation, which is subsequently cleared via tubular secretion by organic ion transporters (OATs; OAT1 and OAT3). Using in v...

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Detaylı Bibliyografya
Yayımlandı:CPT Pharmacometrics Syst Pharmacol
Asıl Yazarlar: Liu, Stephanie N., Desta, Zeruesenay, Gufford, Brandon T.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2019
Konular:
Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6966182/
https://ncbi.nlm.nih.gov/pubmed/31749296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12481
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