Probenecid‐Boosted Tenofovir: A Physiologically‐Based Pharmacokinetic Model‐Informed Strategy for On‐Demand HIV Preexposure Prophylaxis

Multiple doses of tenofovir disoproxil fumarate (TDF) together with emtricitabine is effective for HIV preexposure prophylaxis (PrEP). TDF is converted to tenofovir (TFV) in circulation, which is subsequently cleared via tubular secretion by organic ion transporters (OATs; OAT1 and OAT3). Using in v...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:CPT Pharmacometrics Syst Pharmacol
Main Authors: Liu, Stephanie N., Desta, Zeruesenay, Gufford, Brandon T.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6966182/
https://ncbi.nlm.nih.gov/pubmed/31749296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12481
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker