Probenecid‐Boosted Tenofovir: A Physiologically‐Based Pharmacokinetic Model‐Informed Strategy for On‐Demand HIV Preexposure Prophylaxis

Multiple doses of tenofovir disoproxil fumarate (TDF) together with emtricitabine is effective for HIV preexposure prophylaxis (PrEP). TDF is converted to tenofovir (TFV) in circulation, which is subsequently cleared via tubular secretion by organic ion transporters (OATs; OAT1 and OAT3). Using in v...

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Publicat a:CPT Pharmacometrics Syst Pharmacol
Autors principals: Liu, Stephanie N., Desta, Zeruesenay, Gufford, Brandon T.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6966182/
https://ncbi.nlm.nih.gov/pubmed/31749296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12481
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