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Accelerated development of instability-induced osteoarthritis in transgenic mice overexpressing SOST

Objective: Sclerostin (SOST), acting as a Wnt antagonist, has been shown to play a key role in regulating bone homestasis, and has also been linked to osteoarthritis (OA) development. Here, we investigated whether overexpressing SOST could affect OA development after destabilization of the medial me...

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Bibliographische Detailangaben
Veröffentlicht in:Int J Clin Exp Pathol
Hauptverfasser: Zhou, Sheng, Ge, Yuxiang, Li, Yixuan, Bao, Zhengyuan, Yao, Chen, Teng, Huajian, Jiang, Qing
Format: Artigo
Sprache:Inglês
Veröffentlicht: e-Century Publishing Corporation 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6965855/
https://ncbi.nlm.nih.gov/pubmed/31966426
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