Characterization of binding, functional activity, and contractile responses of the selective 5‐HT(1F) receptor agonist lasmiditan

BACKGROUND AND PURPOSE: Triptans are 5‐HT(1B/1D) receptor agonists (that also display 5‐HT(1F) receptor affinity) with antimigraine action, contraindicated in patients with coronary artery disease due to their vasoconstrictor properties. Conversely, lasmiditan was developed as an antimigraine 5‐HT(1...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Br J Pharmacol
Prif Awduron: Rubio‐Beltrán, Eloísa, Labastida‐Ramírez, Alejandro, Haanes, Kristian A., van den Bogaerdt, Antoon, Bogers, Ad J.J.C., Zanelli, Eric, Meeus, Laurent, Danser, A.H. Jan, Gralinski, Michael R., Senese, Peter B., Johnson, Kirk W., Kovalchin, Joseph, Villalón, Carlos M., MaassenVanDenBrink, Antoinette
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley and Sons Inc. 2019
Pynciau:
Research Papers
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6965684/
https://ncbi.nlm.nih.gov/pubmed/31418454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14832
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