Characterization of binding, functional activity, and contractile responses of the selective 5‐HT(1F) receptor agonist lasmiditan

BACKGROUND AND PURPOSE: Triptans are 5‐HT(1B/1D) receptor agonists (that also display 5‐HT(1F) receptor affinity) with antimigraine action, contraindicated in patients with coronary artery disease due to their vasoconstrictor properties. Conversely, lasmiditan was developed as an antimigraine 5‐HT(1...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Rubio‐Beltrán, Eloísa, Labastida‐Ramírez, Alejandro, Haanes, Kristian A., van den Bogaerdt, Antoon, Bogers, Ad J.J.C., Zanelli, Eric, Meeus, Laurent, Danser, A.H. Jan, Gralinski, Michael R., Senese, Peter B., Johnson, Kirk W., Kovalchin, Joseph, Villalón, Carlos M., MaassenVanDenBrink, Antoinette
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6965684/
https://ncbi.nlm.nih.gov/pubmed/31418454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14832
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