Effects of two isometheptene enantiomers in isolated human blood vessels and rat middle meningeal artery – potential antimigraine efficacy

BACKGROUND: Racemic isometheptene [(RS)-isometheptene] is an antimigraine drug that due to its cardiovascular side-effects was separated into its enantiomers, (R)- and (S)-isometheptene. This study set out to characterize the contribution of each enantiomer to its vasoactive profile. Moreover, rat n...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Headache Pain
Main Authors: Labastida-Ramírez, Alejandro, Rubio-Beltrán, Eloísa, Haanes, Kristian A., de Vries, René, Dammers, Ruben, Bogers, A. J. J. C., van den Bogaerdt, Antoon, Daugherty, Bruce L., Danser, Alexander H. J., Villalón, Carlos M., MaassenVanDenBrink, Antoinette
Format: Artigo
Jezik:Inglês
Izdano: Springer Milan 2019
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6734216/
https://ncbi.nlm.nih.gov/pubmed/31053059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s10194-019-1003-2
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