Characterization of binding, functional activity, and contractile responses of the selective 5‐HT(1F) receptor agonist lasmiditan

BACKGROUND AND PURPOSE: Triptans are 5‐HT(1B/1D) receptor agonists (that also display 5‐HT(1F) receptor affinity) with antimigraine action, contraindicated in patients with coronary artery disease due to their vasoconstrictor properties. Conversely, lasmiditan was developed as an antimigraine 5‐HT(1...

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Vydáno v:Br J Pharmacol
Hlavní autoři: Rubio‐Beltrán, Eloísa, Labastida‐Ramírez, Alejandro, Haanes, Kristian A., van den Bogaerdt, Antoon, Bogers, Ad J.J.C., Zanelli, Eric, Meeus, Laurent, Danser, A.H. Jan, Gralinski, Michael R., Senese, Peter B., Johnson, Kirk W., Kovalchin, Joseph, Villalón, Carlos M., MaassenVanDenBrink, Antoinette
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2019
Témata:
Research Papers
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6965684/
https://ncbi.nlm.nih.gov/pubmed/31418454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14832
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