Characterization of binding, functional activity, and contractile responses of the selective 5‐HT(1F) receptor agonist lasmiditan

BACKGROUND AND PURPOSE: Triptans are 5‐HT(1B/1D) receptor agonists (that also display 5‐HT(1F) receptor affinity) with antimigraine action, contraindicated in patients with coronary artery disease due to their vasoconstrictor properties. Conversely, lasmiditan was developed as an antimigraine 5‐HT(1...

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Sparad:
Bibliografiska uppgifter
I publikationen:Br J Pharmacol
Huvudupphovsmän: Rubio‐Beltrán, Eloísa, Labastida‐Ramírez, Alejandro, Haanes, Kristian A., van den Bogaerdt, Antoon, Bogers, Ad J.J.C., Zanelli, Eric, Meeus, Laurent, Danser, A.H. Jan, Gralinski, Michael R., Senese, Peter B., Johnson, Kirk W., Kovalchin, Joseph, Villalón, Carlos M., MaassenVanDenBrink, Antoinette
Materialtyp: Artigo
Språk:Inglês
Publicerad: John Wiley and Sons Inc. 2019
Ämnen:
Research Papers
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6965684/
https://ncbi.nlm.nih.gov/pubmed/31418454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14832
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