Praziquantel ameliorates CCl(4)‐induced liver fibrosis in mice by inhibiting TGF‐β/Smad signalling via up‐regulating Smad7 in hepatic stellate cells

BACKGROUND AND PURPOSE: Praziquantel is a schistosomicide, which has been used for more than 30 years due to its efficiency, safety, and mild side effects. Previous studies showed that prolonged treatment with praziquantel suppressed the development of liver fibrosis in mice with schistosomiasis. In...

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Dettagli Bibliografici
Pubblicato in:Br J Pharmacol
Autori principali: Liu, Jinfeng, Kong, Delong, Qiu, Jingfan, Xie, Yanci, Lu, Zhongkui, Zhou, Chunlei, Liu, Xinjian, Zhang, Rong, Wang, Yong
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2019
Soggetti:
Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6965681/
https://ncbi.nlm.nih.gov/pubmed/31412137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14831
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