Praziquantel ameliorates CCl(4)‐induced liver fibrosis in mice by inhibiting TGF‐β/Smad signalling via up‐regulating Smad7 in hepatic stellate cells

BACKGROUND AND PURPOSE: Praziquantel is a schistosomicide, which has been used for more than 30 years due to its efficiency, safety, and mild side effects. Previous studies showed that prolonged treatment with praziquantel suppressed the development of liver fibrosis in mice with schistosomiasis. In...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Liu, Jinfeng, Kong, Delong, Qiu, Jingfan, Xie, Yanci, Lu, Zhongkui, Zhou, Chunlei, Liu, Xinjian, Zhang, Rong, Wang, Yong
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6965681/
https://ncbi.nlm.nih.gov/pubmed/31412137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.14831
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