The nuclear translocation of transketolase inhibits the farnesoid receptor expression by promoting the binding of HDAC3 to FXR promoter in hepatocellular carcinoma cell lines

Transketolase (TKT), which is a metabolic enzyme in the nonoxidative phase of the pentose phosphate pathway (PPP), plays an important role in providing cancer cells with raw materials for macromolecular biosynthesis. The ectopic expression of TKT in hepatocellular carcinoma (HCC) was reported previo...

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Udgivet i:Cell Death Dis
Main Authors: Li, Minle, Zhang, Xuping, Lu, Ying, Meng, Sen, Quan, Haoyu, Hou, Pingfu, Tong, Pan, Chai, Dafei, Gao, Xiaoge, Zheng, Junnian, Tong, Xuemei, Bai, Jin
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6965636/
https://ncbi.nlm.nih.gov/pubmed/31949131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2225-6
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