The nuclear translocation of transketolase inhibits the farnesoid receptor expression by promoting the binding of HDAC3 to FXR promoter in hepatocellular carcinoma cell lines

Transketolase (TKT), which is a metabolic enzyme in the nonoxidative phase of the pentose phosphate pathway (PPP), plays an important role in providing cancer cells with raw materials for macromolecular biosynthesis. The ectopic expression of TKT in hepatocellular carcinoma (HCC) was reported previo...

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Publicado no:Cell Death Dis
Main Authors: Li, Minle, Zhang, Xuping, Lu, Ying, Meng, Sen, Quan, Haoyu, Hou, Pingfu, Tong, Pan, Chai, Dafei, Gao, Xiaoge, Zheng, Junnian, Tong, Xuemei, Bai, Jin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6965636/
https://ncbi.nlm.nih.gov/pubmed/31949131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-2225-6
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