Chemical Diversity of Locked Nucleic Acid-Modified Antisense Oligonucleotides Allows Optimization of Pharmaceutical Properties

The identification of molecules that can modulate RNA or protein function and the subsequent chemical and structural optimization to refine such molecules into drugs is a key activity in drug discovery. Here, we explored the extent to which chemical and structural differences in antisense oligonucle...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Ther Nucleic Acids
Hauptverfasser: Papargyri, Natalia, Pontoppidan, Malene, Andersen, Mikael R., Koch, Troels, Hagedorn, Peter H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6965521/
https://ncbi.nlm.nih.gov/pubmed/31951854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2019.12.011
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