Crystal structures of fukutin-related protein (FKRP), a ribitol-phosphate transferase related to muscular dystrophy

α-Dystroglycan (α-DG) is a highly-glycosylated surface membrane protein. Defects in the O-mannosyl glycan of α-DG cause dystroglycanopathy, a group of congenital muscular dystrophies. The core M3 O-mannosyl glycan contains tandem ribitol-phosphate (RboP), a characteristic feature first found in mamm...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Kuwabara, Naoyuki, Imae, Rieko, Manya, Hiroshi, Tanaka, Tomohiro, Mizuno, Mamoru, Tsumoto, Hiroki, Kanagawa, Motoi, Kobayashi, Kazuhiro, Toda, Tatsushi, Senda, Toshiya, Endo, Tamao, Kato, Ryuichi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6965139/
https://ncbi.nlm.nih.gov/pubmed/31949166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14220-z
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