Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer

Mismatch repair deficient (dMMR) gastro-oesophageal adenocarcinomas (GOAs) show better outcomes than their MMR-proficient counterparts and high immunotherapy sensitivity. The hypermutator-phenotype of dMMR tumours theoretically enables high evolvability but their evolution has not been investigated....

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Bibliographic Details
Published in:Nat Commun
Main Authors: von Loga, Katharina, Woolston, Andrew, Punta, Marco, Barber, Louise J., Griffiths, Beatrice, Semiannikova, Maria, Spain, Georgia, Challoner, Benjamin, Fenwick, Kerry, Simon, Ronald, Marx, Andreas, Sauter, Guido, Lise, Stefano, Matthews, Nik, Gerlinger, Marco
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6965135/
https://ncbi.nlm.nih.gov/pubmed/31949146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13915-7
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