Extreme intratumour heterogeneity and driver evolution in mismatch repair deficient gastro-oesophageal cancer

Mismatch repair deficient (dMMR) gastro-oesophageal adenocarcinomas (GOAs) show better outcomes than their MMR-proficient counterparts and high immunotherapy sensitivity. The hypermutator-phenotype of dMMR tumours theoretically enables high evolvability but their evolution has not been investigated....

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Publicat a:Nat Commun
Autors principals: von Loga, Katharina, Woolston, Andrew, Punta, Marco, Barber, Louise J., Griffiths, Beatrice, Semiannikova, Maria, Spain, Georgia, Challoner, Benjamin, Fenwick, Kerry, Simon, Ronald, Marx, Andreas, Sauter, Guido, Lise, Stefano, Matthews, Nik, Gerlinger, Marco
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6965135/
https://ncbi.nlm.nih.gov/pubmed/31949146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13915-7
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