Astrocyte senescence promotes glutamate toxicity in cortical neurons

Neurodegeneration is a major age-related pathology. Cognitive decline is characteristic of patients with Alzheimer’s and related dementias and cancer patients after chemo- or radio-therapies. A recently emerged driver of these and other age-related pathologies is cellular senescence, a cell fate tha...

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Udgivet i:PLoS One
Main Authors: Limbad, Chandani, Oron, Tal Ronnen, Alimirah, Fatouma, Davalos, Albert R., Tracy, Tara E., Gan, Li, Desprez, Pierre-Yves, Campisi, Judith
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6964973/
https://ncbi.nlm.nih.gov/pubmed/31945125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0227887
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