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Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype
Processes that have been linked to aging and cancer include an inflammatory milieu driven by senescent cells. Senescent cells lose the ability to divide, essentially irreversibly, and secrete numerous proteases, cytokines and growth factors, termed the senescence-associated secretory phenotype (SASP...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5799282/ https://ncbi.nlm.nih.gov/pubmed/29402901 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20000-4 |
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