Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype

Processes that have been linked to aging and cancer include an inflammatory milieu driven by senescent cells. Senescent cells lose the ability to divide, essentially irreversibly, and secrete numerous proteases, cytokines and growth factors, termed the senescence-associated secretory phenotype (SASP...

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Udgivet i:Sci Rep
Main Authors: Wiley, Christopher D., Schaum, Nicholas, Alimirah, Fatouma, Lopez-Dominguez, Jose Alberto, Orjalo, Arturo V., Scott, Gary, Desprez, Pierre-Yves, Benz, Christopher, Davalos, Albert R., Campisi, Judith
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5799282/
https://ncbi.nlm.nih.gov/pubmed/29402901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-20000-4
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