Targeting aerobic glycolysis by dichloroacetate improves Newcastle disease virus-mediated viro-immunotherapy in hepatocellular carcinoma

BACKGROUND: Oncolytic viro-immunotherapy holds promise for cancer treatment. While immune activation can be robustly triggered by oncolytic viruses, negative feedback is often upregulated in the tumour microenvironment (TME). Lactate accumulation, signal transducer and activator of transcription 3 (...

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Vydáno v:Br J Cancer
Hlavní autoři: Meng, Gang, Li, Binghua, Chen, Anxian, Zheng, Meihong, Xu, Tiancheng, Zhang, Hailin, Dong, Jie, Wu, Junhua, Yu, Decai, Wei, Jiwu
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6964686/
https://ncbi.nlm.nih.gov/pubmed/31819179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-019-0639-7
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