Targeting aerobic glycolysis by dichloroacetate improves Newcastle disease virus-mediated viro-immunotherapy in hepatocellular carcinoma

BACKGROUND: Oncolytic viro-immunotherapy holds promise for cancer treatment. While immune activation can be robustly triggered by oncolytic viruses, negative feedback is often upregulated in the tumour microenvironment (TME). Lactate accumulation, signal transducer and activator of transcription 3 (...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Meng, Gang, Li, Binghua, Chen, Anxian, Zheng, Meihong, Xu, Tiancheng, Zhang, Hailin, Dong, Jie, Wu, Junhua, Yu, Decai, Wei, Jiwu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6964686/
https://ncbi.nlm.nih.gov/pubmed/31819179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-019-0639-7
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