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Insights into the Binding Recognition and Susceptibility of Tofacitinib toward Janus Kinases

[Image: see text] Janus kinases (JAKs) are enzymes involved in signaling pathways that affect hematopoiesis and immune cell functions. JAK1, JAK2, and JAK3 play different roles in numerous diseases of the immune system and have also been considered as potential targets for cancer therapy. In the pre...

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Detalhes bibliográficos
Publicado no:ACS Omega
Main Authors: Sanachai, Kamonpan, Mahalapbutr, Panupong, Choowongkomon, Kiattawee, Poo-arporn, Rungtiva P., Wolschann, Peter, Rungrotmongkol, Thanyada
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6964278/
https://ncbi.nlm.nih.gov/pubmed/31956784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.9b02800
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