Analysis of Resistance of Ebola Virus Glycoprotein-Driven Entry Against MDL28170, An Inhibitor of Cysteine Cathepsins

Ebola virus (EBOV) infection can cause severe and frequently fatal disease in human patients. The EBOV glycoprotein (GP) mediates viral entry into host cells. For this, GP depends on priming by the pH-dependent endolysosomal cysteine proteases cathepsin B (CatB) and, to a lesser degree, cathepsin L...

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Vydáno v:Pathogens
Hlavní autoři: Hoffmann, Markus, Kaufmann, Svenja Victoria, Fischer, Carina, Maurer, Wiebke, Moldenhauer, Anna-Sophie, Pöhlmann, Stefan
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6963435/
https://ncbi.nlm.nih.gov/pubmed/31618932
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pathogens8040192
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