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Uncoupled turnover disrupts mitochondrial quality control in diabetic retinopathy

Mitochondrial quality control (MQC) is crucial for regulating CNS homeostasis, and its disruption has been implicated in the pathogenesis of some of the most common neurodegenerative diseases. In healthy tissues, the maintenance of MQC depends upon an exquisite balance between mitophagy (removal of...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Hombrebueno, Jose R., Cairns, Lauren, Dutton, Louise R., Lyons, Timothy J., Brazil, Derek P., Moynagh, Paul, Curtis, Tim M., Xu, Heping
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6962019/
https://ncbi.nlm.nih.gov/pubmed/31661466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.129760
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