Evaluation of KRAS, NRAS and BRAF mutations detection in plasma using an automated system for patients with metastatic colorectal cancer

BACKGROUND: Cell-free DNA detection is becoming a surrogate assay for tumor genotyping. Biological fluids often content a very low amount of cell-free tumor DNA and assays able to detect very low allele frequency mutant with a few quantities of DNA are required. We evaluated the ability of the fully...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Franczak, Claire, Witz, Andréa, Geoffroy, Karen, Demange, Jessica, Rouyer, Marie, Husson, Marie, Massard, Vincent, Gavoille, Céline, Lambert, Aurélien, Gilson, Pauline, Gambier, Nicolas, Scala-Bertola, Julien, Merlin, Jean-Louis, Harlé, Alexandre
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6961936/
https://ncbi.nlm.nih.gov/pubmed/31940389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0227294
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