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Uncommon mutational profiles of metastatic colorectal cancer detected during routine genotyping using next generation sequencing
RAS genotyping is mandatory to predict anti-EGFR monoclonal antibodies (mAbs) therapy resistance and BRAF genotyping is a relevant prognosis marker in patients with metastatic colorectal cancer. Although the role of hotspot mutations is well defined, the impact of uncommon mutations is still unknown...
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| 發表在: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group UK
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6506598/ https://ncbi.nlm.nih.gov/pubmed/31068650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43646-0 |
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