Uncommon mutational profiles of metastatic colorectal cancer detected during routine genotyping using next generation sequencing

RAS genotyping is mandatory to predict anti-EGFR monoclonal antibodies (mAbs) therapy resistance and BRAF genotyping is a relevant prognosis marker in patients with metastatic colorectal cancer. Although the role of hotspot mutations is well defined, the impact of uncommon mutations is still unknown...

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Vydáno v:Sci Rep
Hlavní autoři: Franczak, Claire, Kandathil, Shaun M., Gilson, Pauline, Husson, Marie, Rouyer, Marie, Demange, Jessica, Leroux, Agnès, Merlin, Jean-Louis, Harlé, Alexandre
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6506598/
https://ncbi.nlm.nih.gov/pubmed/31068650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43646-0
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