USP12 translocation maintains interferon antiviral efficacy by inhibiting CBP acetyltransferase activity

CREB-binding protein (CBP) participates in numerous transcription events. However, cell-intrinsic inhibitors of CBP are poorly defined. Here, we found that cellular USP12 interacts with the HAT domain of CBP and inhibits CBP’s acetyltransferase activity. Interestingly, USP12 positively regulates int...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:PLoS Pathog
Egile Nagusiak: Liu, Jin, Jin, Lincong, Chen, Xiangjie, Yuan, Yukang, Zuo, Yibo, Miao, Ying, Feng, Qian, Zhang, Hongguang, Huang, Fan, Guo, Tingting, Zhang, Liting, Zhu, Li, Qian, Feng, Zhu, Chuanwu, Zheng, Hui
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Public Library of Science 2020
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6961928/
https://ncbi.nlm.nih.gov/pubmed/31899788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008215
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