USP12 translocation maintains interferon antiviral efficacy by inhibiting CBP acetyltransferase activity

CREB-binding protein (CBP) participates in numerous transcription events. However, cell-intrinsic inhibitors of CBP are poorly defined. Here, we found that cellular USP12 interacts with the HAT domain of CBP and inhibits CBP’s acetyltransferase activity. Interestingly, USP12 positively regulates int...

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Veröffentlicht in:PLoS Pathog
Hauptverfasser: Liu, Jin, Jin, Lincong, Chen, Xiangjie, Yuan, Yukang, Zuo, Yibo, Miao, Ying, Feng, Qian, Zhang, Hongguang, Huang, Fan, Guo, Tingting, Zhang, Liting, Zhu, Li, Qian, Feng, Zhu, Chuanwu, Zheng, Hui
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2020
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6961928/
https://ncbi.nlm.nih.gov/pubmed/31899788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008215
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