Ubiquitin-dependent Turnover of Adenosine Deaminase Acting on RNA 1 (ADAR1) Is Required for Efficient Antiviral Activity of Type I Interferon

Adenosine deaminase acting on RNA 1 (ADAR1) catalyzes RNA editing of cellular and viral RNAs. Besides RNA editing, ADAR1 has recently been shown to play important roles in maintaining the body balance, including tissue homoeostasis, organ development, and autoimmune regulations, by inhibiting both I...

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Опубликовано в: :J Biol Chem
Главные авторы: Li, Lemin, Qian, Guanghui, Zuo, Yibo, Yuan, Yukang, Cheng, Qiao, Guo, Tingting, Liu, Jin, Liu, Chang, Zhang, Liting, Zheng, Hui
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2016
Предметы:
Immunology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5122768/
https://ncbi.nlm.nih.gov/pubmed/27729454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.737098
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