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Adenosine Deaminase Acting on RNA 1 (ADAR1) Suppresses the Induction of Interferon by Measles Virus

ADAR1, the interferon (IFN)-inducible adenosine deaminase acting on RNA, catalyzes the C-6 deamination of adenosine (A) to produce inosine (I) in RNA substrates with a double-stranded character. Because double-stranded RNA is a known inducer of IFN, we tested the role of ADAR1 in IFN induction follo...

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Bibliographic Details
Main Authors: Li, Zhiqun, Okonski, Kristina M., Samuel, Charles E.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302501/
https://ncbi.nlm.nih.gov/pubmed/22278222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06307-11
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