USP12 translocation maintains interferon antiviral efficacy by inhibiting CBP acetyltransferase activity

CREB-binding protein (CBP) participates in numerous transcription events. However, cell-intrinsic inhibitors of CBP are poorly defined. Here, we found that cellular USP12 interacts with the HAT domain of CBP and inhibits CBP’s acetyltransferase activity. Interestingly, USP12 positively regulates int...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:PLoS Pathog
Main Authors: Liu, Jin, Jin, Lincong, Chen, Xiangjie, Yuan, Yukang, Zuo, Yibo, Miao, Ying, Feng, Qian, Zhang, Hongguang, Huang, Fan, Guo, Tingting, Zhang, Liting, Zhu, Li, Qian, Feng, Zhu, Chuanwu, Zheng, Hui
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6961928/
https://ncbi.nlm.nih.gov/pubmed/31899788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008215
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker