Structure-function analyses of candidate small molecule RPN13 inhibitors with antitumor properties

We sought to design ubiquitin-proteasome system inhibitors active against solid cancers by targeting ubiquitin receptor RPN13 within the proteasome’s 19S regulatory particle. The prototypic bis-benzylidine piperidone-based inhibitor RA190 is a michael acceptor that adducts Cysteine 88 of RPN13. In p...

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Bibliographic Details
Published in:PLoS One
Main Authors: Anchoori, Ravi K., Tan, Marietta, Tseng, Ssu-Hsueh, Peng, Shiwen, Soong, Ruey-Shyang, Algethami, Aliyah, Foran, Palmer, Das, Samarjit, Wang, Chenguang, Wang, Tian-Li, Liang, Hong, Hung, Chien-Fu, Roden, Richard B. S.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2020
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6961910/
https://ncbi.nlm.nih.gov/pubmed/31940398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0227727
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