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Hippo pathway effectors YAP/TAZ as novel determinants of ferroptosis

Ferroptosis is a novel form of programmed cell death. We found that the ferroptosis sensitivity in renal and ovarian cancers are regulated by cell density through TAZ-EMP1-NOX4 and TAZ-ANGPTL4-NOX2 pathway, respectively. These findings reveal TAZ as a novel genetic determinant of ferroptosis. Trigge...

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Detalles Bibliográficos
Publicado en:Mol Cell Oncol
Main Authors: Yang, Wen-Hsuan, Chi, Jen-Tsan
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2019
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6961671/
https://ncbi.nlm.nih.gov/pubmed/31993503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2019.1699375
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