Airway epithelial specific deletion of Jun-N-terminal kinase 1 attenuates pulmonary fibrosis in two independent mouse models

The stress-induced kinase, c-Jun-N-terminal kinase 1 (JNK1) has previously been implicated in the pathogenesis of lung fibrosis. However, the exact cell type(s) wherein JNK1 exerts its pro-fibrotic role(s) remained enigmatic. Herein we demonstrate prominent activation of JNK in bronchial epithelia u...

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Udgivet i:PLoS One
Main Authors: van der Velden, Jos L., Alcorn, John F., Chapman, David G., Lundblad, Lennart K. A., Irvin, Charles G., Davis, Roger J., Butnor, Kelly, Janssen-Heininger, Yvonne M. W.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6959564/
https://ncbi.nlm.nih.gov/pubmed/31935227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0226904
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