c-Jun N-Terminal Kinase 1 Is Required for the Development of Pulmonary Fibrosis

Eitemau Tebyg

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• Airway epithelial specific deletion of Jun-N-terminal kinase 1 attenuates pulmonary fibrosis in two independent mouse models
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• Differential Requirement for c-Jun N-terminal Kinase 1 in Lung Inflammation and Host Defense
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• Reactive Nitrogen Species-Induced Cell Death Requires Fas-Dependent Activation of c-Jun N-Terminal Kinase
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• Absence of c-Jun NH(2)-terminal kinase 1 protects against house dust mite-induced pulmonary remodeling but not airway hyperresponsiveness and inflammation
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