Absence of c-Jun NH(2)-terminal kinase 1 protects against house dust mite-induced pulmonary remodeling but not airway hyperresponsiveness and inflammation

Chronic allergic asthma leads to airway remodeling and subepithelial fibrosis via mechanisms not fully understood. Airway remodeling is amplified by profibrotic mediators, such as transforming growth factor-β1 (TGF-β1), which plays a cardinal role in various models of fibrosis. We recently have iden...

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Hauptverfasser: van der Velden, Jos L. J., Hoffman, Sidra M., Alcorn, John F., Tully, Jane E., Chapman, David G., Lahue, Karolyn G., Guala, Amy S., Lundblad, Lennart K. A., Aliyeva, Minara, Daphtary, Nirav, Irvin, Charles G., Janssen-Heininger, Yvonne M. W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2014
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4010650/
https://ncbi.nlm.nih.gov/pubmed/24610935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00153.2013
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