Protein Disulfide Isomerase-ERp57 regulates allergen-induced airways inflammation, fibrosis and hyperresponsiveness

BACKGROUND: Evidence for association between asthma and the unfolded protein response (UPR) is emerging. ERp57 is an ER localized redox chaperone involved in folding and secretion of glycoproteins. We have previously demonstrated that ERp57 is up regulated in allergen-challenged human and murine lun...

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Published in:J Allergy Clin Immunol
Main Authors: Hoffman, Sidra M., Chapman, David G., Lahue, Karolyn G., Cahoon, Jonathon M., Rattu, Gurkiranjit K., Daphtary, Nirav, Aliyeva, Minara, Fortner, Karen A., Erzurum, Serpil C., Comhair, Suzy A.A., Woodruff, Prescott G., Bhakta, Nirav, Dixon, Anne E., Irvin, Charles G., Janssen-Heininger, Yvonne MW., Poynter, Matthew E., Anathy, Vikas
Format: Artigo
Language:Inglês
Published: 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4597791/
https://ncbi.nlm.nih.gov/pubmed/26435004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2015.08.018
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