t-Butyl pyridine and phenyl C-region analogues of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists

A series of 2-substituted 6-t-butylpyridine and 4-t-butylphenyl C-region analogues of 2-(3-fluoro-4-methylsulfonamidophenyl)propanamides were investigated for hTRPV1 antagonism. The analysis of structure activity relationships indicated that the pyridine derivatives generally exhibited a little bett...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Lee, Sunho, Kang, Dong Wook, Ryu, HyungChul, Kim, Changhoon, Ann, Jihyae, Lee, Hobin, Kim, Eunhye, Hong, Sunhye, Choi, Sun, Blumberg, Peter M., Frank-Foltyn, Robert, Bahrenberg, Gregor, Stockhausen, Hannelore, Christoph, Thomas, Lee, Jeewoo
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6959544/
https://ncbi.nlm.nih.gov/pubmed/28314510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2017.03.004
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