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Pyridine C-region analogs of 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides as potent TRPV1 antagonists

A series of pyridine derivatives in the C-region of N-((6-trifluoromethyl-pyridin-3-yl)methyl) 2-(3-fluoro-4-methylsulfonylaminophenyl)propanamides were investigated as hTRPV1 antagonists. The SAR analysis indicated that 6-difluorochloromethyl pyridine derivatives were the best surrogates of the C-r...

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Publicat a:Eur J Med Chem
Autors principals: Ryu, HyungChul, Seo, Sejin, Lee, Jee-Young, Ha, Tae-Hwan, Lee, Sunho, Jung, Aeran, Ann, Jihyae, Kim, Sung-Eun, Yoon, Suyoung, Hong, Mannkyu, Blumberg, Peter M., Frank-Foltyn, Robert, Bahrenberg, Gregor, Schiene, Klaus, Stockhausen, Hannelore, Christoph, Thomas, Frormann, Sven, Lee, Jeewoo
Format: Artigo
Idioma:Inglês
Publicat: 2015
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6959515/
https://ncbi.nlm.nih.gov/pubmed/25659771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2015.02.001
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