Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis

Differentiation and homeostasis of Foxp3(+) regulatory T (Treg) cells are strictly controlled by T-cell receptor (TCR) signals; however, molecular mechanisms that govern these processes are incompletely understood. Here we show that Bach2 is an important regulator of Treg cell differentiation and ho...

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Vydáno v:Nat Commun
Hlavní autoři: Sidwell, Tom, Liao, Yang, Garnham, Alexandra L., Vasanthakumar, Ajithkumar, Gloury, Renee, Blume, Jonas, Teh, Peggy P., Chisanga, David, Thelemann, Christoph, de Labastida Rivera, Fabian, Engwerda, Christian R., Corcoran, Lynn, Kometani, Kohei, Kurosaki, Tomohiro, Smyth, Gordon K., Shi, Wei, Kallies, Axel
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6959360/
https://ncbi.nlm.nih.gov/pubmed/31937752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14112-2
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