Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats

Synaptic dysfunction is hypothesised to play a key role in schizophrenia pathogenesis, but this has not been tested directly in vivo.  Here, we investigated synaptic vesicle glycoprotein 2A (SV2A) levels and their relationship to symptoms and structural brain measures using [(11)C]UCB-J positron emi...

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Bibliografski detalji
Izdano u:Nat Commun
Glavni autori: Onwordi, Ellis Chika, Halff, Els F., Whitehurst, Thomas, Mansur, Ayla, Cotel, Marie-Caroline, Wells, Lisa, Creeney, Hannah, Bonsall, David, Rogdaki, Maria, Shatalina, Ekaterina, Reis Marques, Tiago, Rabiner, Eugenii A., Gunn, Roger N., Natesan, Sridhar, Vernon, Anthony C., Howes, Oliver D.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6959348/
https://ncbi.nlm.nih.gov/pubmed/31937764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14122-0
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