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Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats

Synaptic dysfunction is hypothesised to play a key role in schizophrenia pathogenesis, but this has not been tested directly in vivo.  Here, we investigated synaptic vesicle glycoprotein 2A (SV2A) levels and their relationship to symptoms and structural brain measures using [(11)C]UCB-J positron emi...

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發表在:Nat Commun
Main Authors: Onwordi, Ellis Chika, Halff, Els F., Whitehurst, Thomas, Mansur, Ayla, Cotel, Marie-Caroline, Wells, Lisa, Creeney, Hannah, Bonsall, David, Rogdaki, Maria, Shatalina, Ekaterina, Reis Marques, Tiago, Rabiner, Eugenii A., Gunn, Roger N., Natesan, Sridhar, Vernon, Anthony C., Howes, Oliver D.
格式: Artigo
語言:Inglês
出版: Nature Publishing Group UK 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6959348/
https://ncbi.nlm.nih.gov/pubmed/31937764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14122-0
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