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Phase separation of TPX2 enhances and spatially coordinates microtubule nucleation

Phase separation of substrates and effectors is proposed to enhance biological reaction rates and efficiency. Targeting protein for Xklp2 (TPX2) is an effector of branching microtubule nucleation in spindles and functions with the substrate tubulin by an unknown mechanism. Here we show that TPX2 pha...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: King, Matthew R., Petry, Sabine
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6959270/
https://ncbi.nlm.nih.gov/pubmed/31937751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14087-0
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