JS-K; a nitric oxide-releasing prodrug, modulates β-catenin/TCF signaling in leukemic Jurkat cells: Evidence of an S-nitrosylated mechanism

β-Catenin is a central player of the Wnt signaling pathway that regulates cell–cell adhesion and may promote leukemia cell proliferation. We examined whether JS-K, an NO-donating prodrug, modulates the Wnt/β-catenin/TCF-4 signaling pathway in Jurkat T-Acute Lymphoblastic Leukemia cells. JS-K inhibit...

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Published in:Biochem Pharmacol
Main Authors: Nath, Niharika, Chattopadhyay, Mitali, Pospishil, Liliya, Cieciura, Lucyna Z., Goswami, Satindra, Kodela, Ravinder, Saavedra, Joseph E., Keefer, Larry K., Kashfi, Khosrow
Format: Artigo
Language:Inglês
Published: 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6959133/
https://ncbi.nlm.nih.gov/pubmed/20797387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2010.08.011
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