CaMKII versus DAPK1 Binding to GluN2B in Ischemic Neuronal Cell Death after Resuscitation from Cardiac Arrest

DAPK1 binding to GluN2B was prominently reported to mediate ischemic cell death in vivo. DAPK1 and CaMKII bind to the same GluN2B region, and their binding is mutually exclusive. Here, we show that mutating the binding region on GluN2B (L1298A/ R1300Q) protected against neuronal cell death induced b...

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Veröffentlicht in:Cell Rep
Hauptverfasser: Buonarati, Olivia R., Cook, Sarah G., Goodell, Dayton J., Chalmers, Nicholas E., Rumian, Nicole L., Tullis, Jonathan E., Restrepo, Susana, Coultrap, Steven J., Quillinan, Nidia, Herson, Paco S., Bayer, K. Ulrich
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6959131/
https://ncbi.nlm.nih.gov/pubmed/31914378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.11.076
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