JNK/AP1 Pathway Regulates MYC Expression and BCR Signaling through Ig Enhancers in Burkitt Lymphoma Cells

In Burkitt lymphoma (BL), a chromosomal translocation by which the MYC gene is fused to an immunoglobulin (Ig) gene locus is frequently found. The translocated MYC gene is overexpressed, which is the major driver of BL tumorigenesis. Studies have shown that Ig enhancers are essential for MYC overexp...

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Veröffentlicht in:J Cancer
Hauptverfasser: Ding, Xiaoling, Wang, Xiaoying, Zhu, Xueting, Zhang, Jie, Zhu, Yiqing, Shao, Xiaoyi, Zhou, Xiaorong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ivyspring International Publisher 2020
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6959055/
https://ncbi.nlm.nih.gov/pubmed/31942184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/jca.34055
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