Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation

Lysosomes are membrane-surrounded cytoplasmic organelles filled with a powerful cocktail of hydrolases. Besides degrading cellular constituents inside the lysosomal lumen, lysosomal hydrolases promote tissue remodeling when delivered to the extracellular space and cell death when released to the cyt...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Hämälistö, Saara, Stahl, Jonathan Lucien, Favaro, Elena, Yang, Qing, Liu, Bin, Christoffersen, Line, Loos, Ben, Guasch Boldú, Claudia, Joyce, Johanna A., Reinheckel, Thomas, Barisic, Marin, Jäättelä, Marja
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6957743/
https://ncbi.nlm.nih.gov/pubmed/31932607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-14009-0
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