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Synthesis and Biological Evaluation of Several Bryostatin Analogues Bearing a Diacylglycerol Lactone C-Ring

As an initial step in designing a simplified bryostatin hybrid molecule, three bryostatin analogues bearing a diacylglycerol lactone-based C-ring, which possessed the requisite pharmacophores for binding to protein kinase C (PKC) together with a modified bryostatin-like A- and B-ring region, were sy...

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Dades bibliogràfiques
Publicat a:J Org Chem
Autors principals: Baumann, David O., McGowan, Kevin M., Kedei, Noemi, Peach, Megan L., Blumberg, Peter M., Keck, Gary E.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6957265/
https://ncbi.nlm.nih.gov/pubmed/27494208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.6b01516
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