Discovery of N-(3-fluoro-4-methylsulfonamidomethylphenyl)urea as a potent TRPV1 antagonistic template

A series of homologous analogues of prototype antagonist 1 and its urea surrogate were investigated as hTRPV1 ligands. Through one-carbon elongation in the respective pharmacophoric regions, N-(3-fluoro-4-methylsulfonamidomethylphenyl)urea was identified as a novel and potent TRPV1 antagonistic temp...

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Pubblicato in:Bioorg Med Chem Lett
Autori principali: Ann, Jihyae, Sun, Wei, Zhou, Xing, Jung, Aeran, Baek, Jisoo, Lee, Sunho, Kim, Changhoon, Yoon, Suyoung, Hong, Sunhye, Choi, Sun, Turcios, Noe A., Herold, Brienna K. A., Esch, Timothy E., Lewin, Nancy E., Abramovitz, Adelle, Pearce, Larry V., Blumberg, Peter M., Lee, Jeewoo
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6957248/
https://ncbi.nlm.nih.gov/pubmed/27317643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2016.06.010
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